Sacubitril and valsartan

Generic name: sacubitril and valsartan [sak-UE-bi-tril-and-val-SAR-tan]
Brand name: Entresto is a brand name.
Dosage form: oral pill (24 mg-26 mg; 49 mg-51 mg; 97 mg-103 mg)
Type of drug: Angiotensin receptor agonists and neprilysin inhibitors are a type of drug.

What are sacubitril and valsartan?

Sacubitril and valsartan are used together to treat people with long-term heart failure. Sacubitril and valsartan make it less likely that you will need to go to the hospital if your symptoms get worse. They also make it less likely that you will die from heart failure.

Sacubitril and valsartan are also used to treat heart failure in children who are at least 1 year old.

Most of the time, sacubitril and valsartan are taken with other heart medicines.

Sacubitril and valsartan can also be used for things that aren’t on this list.


Do not use if you are pregnant, and if you become pregnant, tell your doctor right away.

If you have diabetes, you shouldn’t take sacubitril and valsartan with any blood pressure medicine that has aliskiren in it.

Before you take this drug,

You should not take sacubitril and valsartan if you are allergic to sacubitril or valsartan (Diovan) or if you have ever had a severe allergic reaction to a blood pressure medicine like

  • an ACE inhibitor (benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril,
    ramipril, trandolapril (Lotensin, Vasotec, Prinivil, Accupril, Mavik, and others); or
  • an ARB–azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan (Atacand, Avapro, Benicar, Diovan, Edarbi, Micardis, Teveten, and others).

You shouldn’t take sacubitril and valsartan within 36 hours before or after taking an ACE inhibitor.

If you have diabetes, you shouldn’t take sacubitril and valsartan with any blood pressure medicine that has aliskiren in it.

If you have kidney disease, you may also need to avoid taking sacubitril and valsartan with aliskiren.

Tell your doctor if you have ever had

  • liver disease,
  • hereditary angioedema; or
  • if you are on a low-salt-diet.

Do not use if you are pregnant, and if you become pregnant, tell your doctor right away. If you take sacubitril or valsartan during your second or third trimester, it could hurt or kill your future child.

If you are breastfeeding, you shouldn’t take this medicine.

What is the right way to take sacubitril and valsartan?

Follow all of the rules on the package of your medicine, and read any tips or instruction sheets that come with it. Your doctor may change your dose from time to time. Follow the directions to the letter.

This medicine can be taken with or without food.

The amounts of sacubitril and valsartan given to children are based on their weight. If your child gets or drops weight, his or her dose needs may change.

If you can’t swallow a pill whole, a doctor can turn it into a drink that you can take by mouth. Tell the doctor if the person taking this medicine has trouble eating the pill.

Before you measure an amount, shake the liquid mouth mixture. Use the measurement syringe that came with the medicine or a device made for measuring medicine doses (not a spoon).

People will need to check your blood pressure often. You may also need to have your kidney health checked.

Keep at room temperature and away from heat and moisture. Toss any mouth solution that hasn’t been used within 15 days of being made. Don’t put the mouth solution in the fridge.

What will happen if I don’t take a dose?

Take the medicine as soon as you can, but skip the dose you missed if your next dose is almost due. Take only one amount at a time.

What happens if I overdose?

Get help from a doctor right away or call 1-800-222-1222 to reach the Poison Help line.

What should I not do while taking sacubitril and valsartan?

If your doctor hasn’t told you to, don’t take potassium supplements or salt alternatives.

If you get up too quickly after sitting or lying down, you might feel dizzy.

Sacubitril and valsartan side effects

If you have rashes, trouble breathing, or swelling in your face, lips, tongue, or throat, you may be having an allergic response. If you are African-American, you may be more likely to have an allergic response.

Also, call your doctor right away if you:

• feel dizzy and like you might pass out;

• are very tired;

• have high potassium, which causes a slow heart rate, weak pulse, weak muscles, and a tingling feeling; or

• have kidney problems, which cause little or no urination, rapid weight gain, painful or hard urination, or swelling in your hands, feet, or ankles.

Some of the most common side effects of sacubitril and valsartan are:

• Kidney troubles;

• Too much potassium;

• Lightheadedness or dizziness;

• Cough.

This isn’t a full list of all possible side effects, and there may be others. You should talk to your doctor about any side effects. You can call 1-800-FDA-1088 to tell FDA about side affects.Home 2. Sacubitril/valsartan PrintSave

What other medicines might interact with sacubitril and valsartan?

Tell your doctor about all the other medicines you take, especially:

• aliskiren;

• lithium;

• any other heart or blood pressure medicines;

• a diuretic or “water pill”;

• medicine or mineral supplements that contain potassium; or

• NSAIDs, such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list doesn’t have everything. Sacubitril and valsartan may interact with other medicines, such as prescription and over-the-counter drugs, vitamins, and herbal items. Not every drug combination that could happen is on this list.

For more details

Remember to keep this and all other medicines out of reach of children, to never give your medicines to other people, and to only use this medicine for what it was given for.

Talk to your doctor or other healthcare source to make sure that the information on this page applies to your situation.

Medical Disclaimer Use Copyright 1996–2023 Cerner Multum, Inc. Version: 5.01.

About the Author: Daniel