Qbrexza (Topical application)

Glycopyrronium tosylate (topical application route) [gly-koe-pir-OH-nee-um TOS-i-late] is the generic name.
Miscellaneous Topical agents are a type of drug.

Brand name(s) that are often used

in the U.S.

• Qbrexza

Available Dosage Forms:

• Pad

Cholinergic antagonist is a type of medicine

Pharmacologic Class: Antimuscarinic

Uses for Qbrexza

Glycopyrronium tosylate is used to treat underarm sweating that happens too much (primary axillary hyperhidrosis).

You can only get this medicine with a prescription from your doctor.

Prior to Taking Qbrexza

To decide whether or not to use a medicine, you have to weigh the risks of taking the medicine against the good it will do. You and your doctor will decide what to do. For this medicine, you should think about the following:


Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicine. Tell your doctor or nurse if you are allergic to anything else, like foods, dyes, preservatives, or animals. Read the label or package carefully to find out what is in non-prescription products.


Appropriate studies have not been done on the effects of glycopyrronium tosylate on children younger than 9 years old and how they change with age. Safety and effectiveness have not been proven.


Appropriate studies done so far haven’t shown any problems that are unique to older people that would make glycopyrronium tosylate less useful for them.


There aren’t enough studies on women to know if using this medicine while breastfeeding is dangerous for the baby. Before taking this medicine while breastfeeding, you should weigh the possible benefits against the possible risks.

Interactions between medicines:

Some medicines should never be taken together, but in other cases, two different medicines can be taken at the same time even if an interaction could happen. In these cases, your doctor may change the dose or tell you to take other precautions. Tell your doctor or nurse if you are also taking any other prescription or over-the-counter (OTC) drugs.

Food/tobacco/alcohol interactions

Some medicines shouldn’t be taken while eating or right after eating, or with certain kinds of food, because they might not work as well. Using alcohol or cigarettes with some medicines can also cause interactions. Talk to your doctor or chemist about how to take your medicine with food, alcohol, or tobacco.

Other health issues

This medicine may not work as well if you have other health problems. Make sure to tell your doctor if you have any other health problems, especially if you have:

  • Bladder problems (like a swollen bladder or a blocked bladder neck) or
  • An enlarged prostate or
  • Trouble passing urine—Use with caution. Could make these things worse.
  • Blood or vessel disease that causes severe bleeding, instability, or
  • Glaucoma or
  • Graves’ disease (nerve or muscle disease) or
  • Sjogren’s syndrome (immune system disorder) or
  • Stomach or bowel problems (like paralytic ileus, severe ulcerative colitis, or toxic megacolon that makes ulcerative colitis worse)—Should not be used in people with these conditions.
  • Kidney disease: Be careful when using. Because the medicine leaves the body more slowly, the effects may be stronger.

How to use Qbrexza correctly

Use this medicine only as your doctor tells you. Do not take more, take it more often, or take it for longer than your doctor told you to.

Only put this medicine on clean, dry skin under your arms. Do not get it in your eyes, nose, or mouth. Do not take the medicine by mouth or put it on skin that is broken.

To use the material/Cloth:

  • Use soap and water to clean your hands before and after taking this medicine.
  • Tear the bag open and pull the cloth out.
  • Unfold the cloth and wipe one armpit with it once.
  • Use the same cloth to wipe the other armpit once.
  • Do not put this medicine on skin that is broken.
  • Do not put a bandage on the area that has been treated unless your doctor tells you to.


Different people will need different amounts of this medicine. Follow what your doctor tells you to do or what it says on the label. The information below only talks about the average amounts of this medicine. Unless your doctor tells you to, don’t change your dose if it’s different.

How much of a medicine you need to take depends on how strong it is. Also, the number of doses you take each day, how long you wait between doses, and how long you take the medicine depend on the health problem you are trying to treat.

  • For topical (cloth) dosage form:
    • For underarm sweating that is too much:
      • Adults and children older than 9 years old should put one cloth on each underarm once every 24 hours.
      • Children younger than 9 years old should talk to their doctor about how to use and how much to use.

Dose Missed

For instructions, call your doctor or chemist.


  • Keep out of children’s reach.
  • Do not keep medicines that are out of date or that you no longer need.
  • Ask your doctor or nurse how you should get rid of medicines you no longer need.
  • Keep the medicine in a sealed container at room temperature, away from direct light, heat, and moisture. Don’t let it get cold.
  • Keep this medicine away from fire or heat.

Care to take when using Qbrexza

It is very important that your doctor check your or your child’s progress at regular visits to make sure this medicine is working well and to look for any side effects.

Don’t use this medicine to treat a skin condition that your doctor hasn’t looked at.

This medicine could make it hard to pass urine or stop you from emptying your bladder completely, especially if your bladder is blocked. Check with your doctor right away if you or your child has less urine, urinates less often, has trouble going to the toilet, feels like they have a full bladder, or it hurts to urinate.

It may be harder for your body to cool down if you take this medicine. It might cause you to sweat less. If you don’t sweat enough, your body could get too hot. If your body gets too hot, you might feel sick, weak, tired, or confused. Stay away from places that are too hot. If drinking cool water and getting out of the heat don’t help you feel better, you should call your doctor.

This medicine could make it hard to see. Don’t drive or do anything else that could be dangerous until you know how this medicine affects you.

Do not take any other medicines unless your doctor has told you to. This includes herbal or vitamin supplements, as well as medicines with or without a prescription (over-the-counter, or OTC).

Qbrexza side effects

A medicine may have some affects you don’t want along with the ones you do. Even though not all of these side effects might happen, if they do, you might need to see a doctor.

Talk to your doctor right away if any of these side effects happen:

Less common

  • Pupils that are bigger, dilated, or enlarged;
  • Blurry vision;
  • Pupils that are different sizes;
  • Trouble urinating

Incidence not known

  • Urinating less often
  • Urine volume going down
  • Trouble emptying your bladder
  • Trouble passing urine (dribbling)
  • Urinating hurts

Some side effects may happen, but most of the time, they don’t need medical help. As your body gets used to the medicine, these side effects might go away. Also, your doctor or nurse might be able to give you advice on how to avoid or lessen some of these side effects. Talk to your doctor if any of the following side effects last or bother you, or if you have any questions about them:

More common

  • a dry mouth, fever, headache, and eyes that are more sensitive to light.
  • muscle aches
  • pain in the mouth or throat
  • red, burning, stinging, or itchy skin
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness

Less Common

  • Constipation
  • Dry eyes
  • Dry skin
  • Dry throat and
  • Dry nose happen less often

Some patients may also have side effects that aren’t on this list. If you have any other side effects, talk to your doctor or nurse.

You should talk to your doctor about any side effects. You can call 1-800-FDA-1088 to tell the FDA about side effects.

Questions that are often asked

  • What is a Qbrexza cloth used for?

More about Qbrexza (glycopyrronium topical):

  • Check interactions
  • Pricing and coupons
  • Reviews (44)
  • Side effects
  • Dosage information
  • During pregnancy
  • History of FDA approval
  • Drug class: miscellaneous topical agents
  • En español

Patient resources

  • Information about drugs
  • Qbrexza

Professional resources

  • Information for doctors and pharmacists

Similar treatment plans

  • Hyperhidrosis

For More Details

Talk to your doctor or other healthcare provider to make sure that the information on this page applies to your situation.

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