Generica Name: The name for this drug on its own is nintedanib.
Type of drug: Multikinase inhibitors are a type of drug.

Who is Ofev?

People who have diseases that cause scar tissue (fibrosis) to form deep in the lungs are given Ofev. Over time, the scar tissue gets thicker and harder, which can make it harder for your lungs to work. If your lungs don’t work as well, it can be hard to breathe. When your brain, heart, and other systems do not get enough oxygen, it can lead to other health problems.

Idiopathic pulmonary fibrosis (IPF) is a lung disease that Ofev is used to treat.

Ofev is also used to treat interstitial lung disease that lasts for a long time and makes scar tissue keep getting worse.

Ofev is also used to help people with a disease called systemic sclerosis-associated interstitial lung disease (sometimes called scleroderma-associated ILD) keep their lung capacity from getting worse.

Ofev is not a fix for IPF or ILD, but it can slow down the damage to your lungs caused by these diseases.


Ofev can cause birth problems or even cause a baby to die in the womb. Don’t try to get pregnant while you’re taking this medicine or for at least 3 months after you’ve finished taking it. Use birth control that works and has an extra barrier (condom, diaphragm, cervical cap, or contraceptive sponge).

Before you take this drug

To make sure Ofev is safe for you, tell your doctor if you have ever had:

  • liver disease;
  • heart problems;
  • a blood clot;
  • bleeding problems (either you or someone in your family);
  • surgery on your stomach or intestines; diverticulitis;
  • if you smoke; or
  • if you take a blood thinner like warfarin (Coumadin, Jantoven).

Before starting this treatment, you may need to make sure that you are not pregnant by taking a test.

Nintedanib can hurt or kill a baby that is still in the womb. Use effective birth control to avoid getting pregnant while you are taking this medicine and for at least 3 months after your last dose. If you get pregnant, you should tell your doctor.

If you use hormonal birth control (like birth control pills, shots, implants, skin patches, or vaginal rings), you should also use a barrier form of birth control to avoid getting pregnant while taking Ofev. A condom, diaphragm, cervical cap, or contraception sponge are all types of barriers.

Women who take Ofev may lose their ability to have children. But it’s important to use birth control to avoid getting pregnant, since this medicine can hurt a developing child.

If you are breastfeeding, you shouldn’t take this medicine.

Ofev shouldn’t be used by anyone under the age of 18.

What dosage of Ofev should I use?

Most people take Ofev twice a day, every 12 hours. Follow all of the rules on the label of your prescription, and read any guides or instruction sheets that come with it. Your doctor may change your dose from time to time.

Your doctor will check your blood to make sure you don’t have any health problems that would make it unsafe for you to use Ofev.

Take with a full glass of water and food.

Do not crush, chew, break, or open the pill. Instead, swallow it whole.

Usually, you should take your amounts every 12 hours.

Ofev can cause serious diarrhea, which can kill you if it makes you lose too much water. You might need to take medicine to stop diarrhea or get rid of it quickly.

While you are taking Ofev, your doctor may tell you to always have loperamide (Imodium) or another medicine to stop diarrhea on hand. Take the medicine for diarrhea as suggested on the label or as your doctor tells you to.

If you get diarrhea while taking Ofev, drink a lot of fluids and call your doctor right away.

You will need to go to the doctor often to make sure that nintedanib is not hurting your liver. Based on the data, your next few doses may be put off.

Keep this medicine in its original bottle at room temperature, away from moisture and heat.

Information dosage

For adults with Idiopathic Pulmonary Fibrosis, the usual dose is 150 mg by mouth every 12 hours.

Maximum dose: 300 mg/day

Comments: -Liver function tests should be done before starting treatment.

-Do a pregnancy test on women who could have children before starting treatment.

Uses: -To treat idiopathic pulmonary fibrosis (IPF) -To slow the rate of decline in respiratory function in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD)

For adults with chronic lung disease, the usual dose is 150 mg every 12 hours.

Maximum dose: 300 mg/day

Comments: -Liver function tests should be done before starting treatment.

-Do a pregnancy test on women who could have children before starting treatment.

Uses: -To treat idiopathic pulmonary fibrosis (IPF) -To slow the rate of decline in respiratory function in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD)

What will happen if I don’t take a dose?

Don’t take the amount you forgot, and take your next dose at the usual time. Don’t take both doses at the same time.

What happens if I overdose?

Get help from a doctor right away or call 1-800-222-1222 to reach the Poison Help line.

Do not take more than 300 milligrams of nintedanib in a single day.

What not to do?

If you smoke, Ofev might not work as well. Don’t smoke while taking this medicine, or try to quit before you start this treatment.

Don’t take a product that has St. John’s wort in it.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) like aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Taking an NSAID with nintedanib could make you more likely to get bruises or bleed.

Ofev side effects

If you are allergic to Ofev and have hives, trouble breathing, or swelling of your face, lips, tongue, or throat, call 911 right away.

Call your doctor right away if:

• severe, long-lasting nausea, vomiting, or diarrhea; • severe stomach pain, bloating, or tenderness; • bleeding from your rectum or blood in your stools; • easy bruising or bleeding, or a wound that won’t heal; • fever, chills, cough with mucus, chest pain, feeling short of breath; • heart attack symptoms, such as chest pain or pressure, pain spreading to your jaw or shoulder, nausea, and sweating; • liver problems, such as stomach pain (

Women, people who weigh less than 143 pounds (65 kilograms), and people of Asian descent may be more likely to have liver troubles.

If you have certain side effects, your next amount may be put off.

Some common side effects of Ofev include nausea, vomiting, loss of hunger, stomach pain, diarrhea, weight loss, high blood pressure, headache, or liver function tests that don’t look right.

This isn’t a full list of all possible side effects, and there may be others. You should talk to your doctor about any side effects. You can call 1-800-FDA-1088 to tell the FDA about side affects.

How will the other drugs affect Ofev?

There are times when it is not safe to take certain medicines together. Some drugs can change how much of another drug is in your blood, which can make side effects worse or make the drug less effective.

Other medicines, such as prescription and over-the-counter drugs, vitamins, and herbal items, may have an effect on nintedanib. Tell your doctor about all the drugs you are taking now, as well as any you start or stop taking.

For more details

Remember to keep this and all other medicines out of the reach of children, to never give your medicines to other people, and to only use Ofev for what it was meant for.

Talk to your doctor or other healthcare source to make sure that the information on this page applies to your situation.

Disclaimer for Medical Use Copyright 1996–2023 Cerner Multum, Inc. Version: 4.01.

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