Generic Name: Palbociclib (pal-boe-SYE-klib), the generic name
Drug Class: CDK 4/6 inhibitors are a class of drugs.
Describe Ibrance.
Ibrance is a cancer drug that prevents the development and metastasis of cancer cells in the body.
Ibrance is used to treat breast cancer that has progressed to other body areas and is HR-positive but HER2-negative in both men and women.
Ibrance is administered to postmenopausal women together with a hormonal medication such letrozole (Femara). Ibrance is sometimes administered in combination with fulvestrant (Faslodex).
Warnings
Your immune system or your lungs may be impacted by ibrance. You can be more susceptible to infections, even serious or fatal ones. If you get a fever, chills, chest pain, shortness of breath, or a cough that produces mucus or not, call your doctor right once.
similar/related medications
Xeloda, Afinitor, Femara, Tamoxifen, Kisqali, Piqray, and Tamoxifen
Prior to using this medication
If you have a palbociclib allergy, you should avoid using Ibrance. If you exhibit infection-related symptoms (such as fever or chills), let your doctor know.
Inform your doctor of any of the following to ensure that Ibrance is safe for you:
• Liver disease; or
• Kidney disease.
If either the mother or the father uses palbociclib, it may harm the unborn child or result in birth abnormalities.
• If you are a woman and you are pregnant, avoid using palbociclib. Before beginning this medication, you might need to get a pregnancy test that is negative. While using this medication and for at least 3 weeks following your last dose, use reliable birth control to avoid getting pregnant.
• If your sexual partner is able to become pregnant, if you are a guy, take reliable birth control. At least three months following your final dose, continue utilizing birth control.
• If a pregnancy arises while either the mother or the father is taking Ibrance, notify your doctor right away.
This medication may have an impact on men’s fertility (capacity to conceive). Palbociclib can harm an unborn child, thus it’s crucial to use birth control to prevent conception.
While using palbociclib and for at least 3 weeks following your final dose, you shouldn’t breastfeed.
How do I administer Ibrance?
Ibrance should be taken exactly as directed. Read all drug guides or instruction sheets and adhere to all instructions on your prescription label. On occasion, your doctor could adjust your dosage.
Ibrance is administered over the course of a 28-day treatment cycle, though you might only need to take it for the first three weeks of each cycle. How long you will receive Ibrance treatment will be decided by your doctor.
With food, take Ibrance pills. Products containing grapefruit should be avoided. Palbociclib and grapefruit may interact and produce undesirable side effects.
Ibrance pills can be taken with or without food.
Take your medication every day at the same time.
Do not chew, break, or otherwise tamper with the capsule or pill; instead, swallow it whole. Useless pills should not be taken.
Ibrance should not be used again until the next day if you vomit after taking it.
It has an impact on your immune system. You can be more susceptible to infections, even serious or fatal ones. You must get routine medical examinations by your doctor.
Keep your items at room temperature away from heat and moisture.
dosage details
Common Adult Breast Cancer Dose:
28-day cycle: 125 mg taken orally once daily for 21 days straight, then 7 days off.
Comments:
-When using this medication along with an aromatase inhibitor, use the appropriate dosage. Consult the prescribing information for the currently being used aromatase inhibitor.
Fulvestrant should be administered in conjunction with this medication at a dose of 500 mg on Days 1, 15, and 29, and then once a month after that. Consult the fulvestrant prescribing information.
-In accordance with local policy, pre/perimenopausal women using this medication in combination with fulvestrant should also get treatment with luteinizing hormone-releasing hormone (LHRH) agonists.
Use: Fulvestrant in patients with disease progression after endocrine therapy for HR-positive, HER2-negative advanced or metastatic breast cancer in combination with an aromatase inhibitor as the initial endocrine-based therapy in postmenopausal women.
What occurs if I don’t take a dose?
Skip the missed dose and wait until the following day to take the medication again. Never combine two dosages at once.
If I take too much, what happens?
Get immediate medical help or dial 1-800-222-1222 for poison help.
what not to do
Stay away from those who are ill or infected. As soon as you notice any infection-related symptoms, call your doctor.
adverse effects of ibrance
If you have any of the following symptoms of an allergic response to Ibrance: hives, trouble breathing, swelling of your face, lips, tongue, or throat, get emergency medical attention.
If you experience any of the following:
• oral ulcers or blisters, red or swollen gums, and difficulty swallowing;
• low blood cell counts – fever, chills, weakness, lightheadedness, vertigo, mouth sores, skin sores, easy bruising, unusual bleeding, pale complexion, cold hands and feet;
• indications of lung inflammation, such as a persistent cough, wheezing, and feeling out of breath even while at rest, or
• symptoms of a blood clot in the lung, such as chest pain, a bloody cough, wheezing, and fast breathing.
If you experience specific adverse effects, your cancer treatments can be postponed or stopped altogether.
Typical adverse reactions to Ibrance include:
• infections, low blood cell levels;
• quick bleeding or bruising;
• feeling lethargic or feeble;
• diarrhoea, vomiting, and appetite loss;
• mouth ulcers
Unusual liver function test results;
• rash and dry skin;
• a changed sense of flavor;
• a runny nose; or
• hair loss or thinning.
There may be additional adverse effects; this is not a comprehensive list. For medical advice about side effects, contact your doctor. Call 1-800-FDA-1088 to report side effects to the FDA.
Which additional medications will impact Ibrance?
Other medications, including prescription and over-the-counter drugs, vitamins, and herbal supplements, may interact with palbociclib. Inform your doctor about all of your existing medications as well as any new or discontinued ones.
additional information
Never share your medications with others, keep this and all other medications out of the reach of children, and only use Ibrance for the specified condition.
Always check with your healthcare practitioner to make sure the details on this page apply to your specific situation.
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