dapagliflozin (generic name) (DAP a gli FLOE zin)
Farxiga is a brand name.
Forms of administration: oral tablet (10 mg; 5 mg)
SGLT-2 inhibitors are a type of medication.
What is dapagliflozin and how does it work?
In individuals with type 2 diabetes, dapagliflozin is combined with diet and exercise to enhance blood sugar management (not for type 1 diabetes).
In individuals with type 2 diabetes and heart disease, dapagliflozin is also used to reduce the chance of needing to go to the hospital for heart failure.
In individuals with type 2 diabetes and heart disease, dapagliflozin is also used to reduce the risk of death from a heart attack, stroke, or heart failure.
In individuals with type 2 diabetes and renal difficulties, dapagliflozin is also used to minimise the risk of end-stage kidney disease, hospitalisation, or death from cardiac problems.
Dapagliflozin can be used for a variety of other things that aren’t covered in this medication guide.
Dapagliflozin has the potential to induce significant infections in the penis or vaginal area. If you have burning, itching, odour, discharge, discomfort, tenderness, redness, or swelling of the vaginal or rectal area, fever, or don’t feel well, seek medical attention immediately once.
Dapagliflozin might cause dehydration, which can make you feel weak and dizzy (especially when you stand up).
Before you start taking any medication, make sure you have everything you need.
You should not take dapagliflozin if you are allergic to it or if you have any of the following conditions:
- if you have serious renal disease (or are on dialysis); or
- Ketoacidosis in diabetics (call your doctor for treatment).
If you’ve ever had any of the following, tell your doctor.
- polycystic kidney disease (PKD) is a type of kidney disease in which the cysts
- illness of the liver;
- Infections of the bladder or other urinary issues;
- blood pressure is low;
- a problem with your pancreas, which may require surgery;
- if you are thirsty;
- if you consume alcohol on a regular basis; or
- if you’re following a low-salt diet
What is the best way to take dapagliflozin?Read all drug guides or instruction sheets and follow all guidelines on your prescription label. Your doctor may adjust your dose from time to time. Follow the medication’s instructions to the letter. Dapagliflozin can be taken with or without food. During a long illness, you may become dehydrated. If you’re unwell with vomiting or diarrhoea, or if you’re eating or drinking less than normal, call your doctor. Hypoglycemia (low blood sugar) might make you feel famished, disoriented, irritated, or unsteady. Eat or drink hard candy, crackers, raisins, fruit juice, or non-diet cola to fast correct hypoglycemia. In the event of extreme hypoglycemia, your doctor may prescribe glucagon injection. Stress, illness, surgery, exercise, alcohol consumption, and meal skipping can all impact blood sugar levels. If you experience regular signs of high blood sugar (hyperglycemia), such as excessive thirst or urine, tell your doctor. Before changing your prescription dose or schedule, consult your doctor.
Certain medical tests may be affected by this medication. Tell every doctor you see that you’re taking dapagliflozin.
Diet, exercise, weight control, and specific medical care may all be part of your treatment plan.
Store away from moisture and heat at room temperature.
What happens if I forget to take a dose?
Take the drug as soon as possible, but if your next dose is approaching, avoid the missed dose. Do not combine two dosages at once.
Seek emergency medical help or dial 1-800-222-1222 to reach the Poison Help line.
What happens if I take too much?
When using dapagliflozin, what should I avoid?
If you stand up too quickly from a sitting or laying position, you may become dizzy.
Side effects of dapagliflozinIf you develop hives, difficulty breathing, or swelling of your face, lips, tongue, or neck, get immediate medical attention. If you experience any of the following symptoms of a genital infection (penis or vagina), get medical help immediately away: burning, itching, odour, discharge, pain, tenderness, redness or swelling of the genital or rectal region, fever, or feeling unwell. These symptoms may rapidly deteriorate. If you experience any of the following symptoms, call your doctor right once.
- urination is little or non-existent;
- Symptoms of dehydration include dizziness, weakness, and a sensation of being light-headed (as if you’re about to pass out).
- Kidney issues include infrequent or no urine, swelling in the feet or ankles, fatigue, and shortness of breath.
- nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing; or ketoacidosis (too much acid in the blood)—nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing; or
- Discomfort or burning while urinating, increased urination, blood in your urine, fever, and pain in your pelvis or back are all symptoms of a bladder infection.
In elderly individuals, side effects may be more common.
The following are some of the most common adverse effects:
- a yeast infection in the vaginal area;
- urinating more often than usual;
- a painful throat and a stuffy or runny nose
Dosage information for dapagliflozinAdult Dosage for Type 2 Diabetes: To enhance glycemic control, do the following: Initial dosage: 5 mg orally once a day; if lower dose is tolerated, increase to 10 mg orally once a day for further glycemic control. 10 mg per day is the maximum dosage. To lower your chances of being admitted to the hospital for heart failure, do the following: Once a day, take 10 mg orally. -Ensure that volume depletion is corrected before starting treatment. -Make sure you have sufficient renal function (eGFR > 45 mL/min/1.73 m2), since glycemic effectiveness is reliant on it. -If used with insulin or an insulin secretagogue, a reduced insulin or insulin secretagogue dosage should be considered to minimise the risk of hypoglycemia. -As a supplement to diet and exercise in individuals with type 2 diabetes mellitus to enhance glycemic control. -To lower the likelihood of heart failure hospitalisation in individuals with type 2 diabetes mellitus and existing cardiovascular disease (CVD) or multiple CV risk factors. Adult Dose for Ejection Fraction Reduction in Heart Failure: Once a day, take 10 mg orally. -Ensure that volume depletion is corrected before starting treatment. Patients with type 1 diabetes should avoid using this medication. Use: To lower the risk of heart failure-related mortality and hospitalisation in individuals with heart failure (NYHA class II-IV) with a low ejection fraction. Dose for Chronic Kidney Disease in Adults: Once a day, take 10 mg orally. -This medication is not advised in patients with polycystic kidney disease or individuals who need, or have recently had, immunosuppressive treatment for kidney disease, since it is not anticipated to be successful. -This medication is not advised for those who have type 1 diabetes. In individuals with chronic renal disease who are at risk of progression, to decrease the risk of persistent eGFR decline, end-stage kidney disease, cardiovascular mortality, and heart failure hospitalisation.
What additional medications will have an effect on dapagliflozin?
Tell your doctor about any additional medications you’re taking, especially:
- insulin or other diabetic medications taken by mouth; or
- a diuretic, often known as a “water pill.”