Generic name: dapagliflozin
brand name: Farxiga is the brand name
Dosage form: mouth tablet
Drug Class: SGLT-2 inhibitors are a type of drug.

What exactly is dapagliflozin?

Dapagliflozin is a prescription drug that is mostly used with a healthy diet and regular exercise to treat type 2 diabetes. It is also used to treat heart failure. The US Food and Drug Administration (FDA) gave it its first green light in 2014.

Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) drug. The kidneys are used by this type of drug to help control the amount of glucose (blood sugar) in your blood. It works by making you pee more, which gets rid of more glucose from your body. It also makes it easier for your heart to get blood to all parts of your body.

What’s the purpose of dapagliflozin?

  • Dapagliflozin is a prescription drug that is used with food and exercise to help adults with type 2 diabetes better control their blood sugar (glucose).
    • To lower the chance that an adult with type 2 diabetes and known heart disease or multiple heart disease risk factors will have to go to the hospital because of heart failure.
    • To lower the risk of death from heart disease and hospitalization for heart failure in adults with heart failure, which happens when the heart is weak and can’t pump enough blood to the rest of the body.
    • To lower the risk of your kidney disease getting worse, getting end-stage kidney disease (ESKD), dying from heart disease, and getting hospitalized for heart failure if you have chronic kidney disease.
    • People with type 1 diabetes should not take dapagliflozin. People with type 1 diabetes may be more likely to get diabetic ketoacidosis, which means they have more ketones in their blood or urine.
  • Dapagliflozin shouldn’t be used to help people with type 2 diabetes and moderate to severe kidney problems control their blood sugar (glucose), because it may not work.
  • Dapagliflozin is not for people with certain genetic forms of polycystic kidney disease or who are taking or have recently taken immunosuppressive treatment to treat kidney disease. If you have any of these problems, dapagliflozin is not likely to help.
  • No one knows if dapagliflozin is safe and useful for kids under 18 years old.

What you need to know

Serious side effects of dapagliflozin include:

  • Dehydration. Some people can lose water and salt from their bodies when they take dapagliflozin. Dehydration can make you feel weak, dizzy, or lightheaded when you stand up (this is called orthostatic hypotension). People with Type 2 diabetes who take dapagliflozin have been said to have sudden kidney damage.
    • If you take drugs to lower your blood pressure, like water pills (diuretics), you may be more likely to get dehydrated.
    • You’re 65 or older
    • You’re on a low-salt diet
    • You have kidney problems.

Talk to your doctor about what you can do to keep from getting dehydrated, including how much water you should drink every day. Call your doctor right away if you can’t eat or drink as much as usual, or if you start to lose fluids from your body because of things like sickness, diarrhea, or being in the sun for too long.

  • Yeast infection in the cervix. If a woman takes dapagliflozin, she may get a yeast problem in her genital area. Some signs of a yeast infection in the genital area are:
    • A smell coming from the vaginal area.
    • A white or yellow discharge from the vaginal area, which may be lumpy or look like cottage cheese.
    • Vaginal pain.
  • Balanitis, or an inflammation of the penis caused by yeast. When men take dapagliflozin, the skin around the penis may get infected with yeast. Some men who haven’t been circumcised may have a swollen penis that makes it hard to pull back the skin around the penis tip. Other signs of a yeast infection in the penis are redness, itching, and swelling.
    • a rash on the penis
    • fluid from the penis that smells bad
    • pain in the skin around the penis

Talk to your doctor about what to do if you think you have a yeast problem in your vaginal area or your penis. Your doctor may tell you to use an antifungal medicine that you can buy without a prescription. If you use an over-the-counter antifungal medicine and your symptoms don’t go away, you should talk to your doctor right away.

Who shouldn’t take this medicine?

Do not take dapagliflozin if you are allergic to it or any of its ingredients. Below is a list of the things that dapagliflozin is made of. If you have a severe allergic response to dapagliflozin, you might experience:

  • Skin Rash
  • hives, which are raised red spots on your skin.
  • swollen face, lips, tongue, and throat, which can make it hard to breathe or swallow.

If you have any of these signs, you should stop taking dapagliflozin and call your doctor or go to the emergency room of the local hospital right away.

  • go through dialysis.

Before I take dapagliflozin, what should I tell my doctor?

Before you take dapagliflozin, tell your doctor if you:

  • have type 1 diabetes or have ever had diabetic ketoacidosis.
  • have liver problems.
  • Have had urinary tract diseases or trouble going to the bathroom in the past.
  • will be having surgery. Before surgery, your doctor may tell you to stop taking dapagliflozin. Talk to your doctor about when to stop taking dapagliflozin and when to start it again if you are going to have surgery.
  • You are eating less or your eating habits have changed.
  • You have or have had stomach problems, like pancreatitis or surgery on your pancreas.
  • Drink a lot of alcohol or drink a lot of alcohol in a short amount of time (“binge” drinking).

What is the best way to take dapagliflozin?

  • Take dapagliflozin exactly as your doctor or nurse tells you.
  • Don’t change the amount of dapagliflozin you take without first talking to your doctor.
  • Take dapagliflozin by mouth once a day, with or without food.
  • Stick to the diet and exercise plan your doctor has given you while taking dapagliflozin.
  • Dapagliflozin will make your urine test positive for glucose.
  • Your doctor may do blood tests before you start taking dapagliflozin and while you are taking it.
  • If you have diabetes,
    • When your body is under stress from things like a fever, a car accident, an infection, or surgery, the amount of diabetes medicine you need may change. If you have any of these problems, you should talk to your doctor right away and do what he or she tells you.
    • If you have diabetes, your doctor will check your blood regularly, looking at things like your blood sugar level and your HbA1c.
    • Do what your doctor or nurse tells you to do to treat low blood sugar (hypoglycemia). Talk to your doctor or nurse if you have trouble with low blood sugar.

What will happen if I don’t take a dose?

If you forget to take a dose, take it as soon as you think about it. If it’s almost time for your next dose, skip the one you missed and take the medicine when it’s time again. Take only one dose of dapagliflozin at a time.

What happens if I overdose?

If you take too much dapagliflozin, you should call your doctor or go to the emergency room as soon as possible.

Information dosage

  • Estimated glomerular filtration rate (eGFR) 45 mL/min/1.73m2 or greater: For better control of blood sugar, the starting amount is 5 mg once a day. For better control of blood sugar, the dose can be raised to 10 mg once a day. For all other uses, the starting amount is 10 mg taken by mouth once a day.
  • eGFR 25 mL/min/1.73m2 to less than 45: 10 mg orally once a day
  • eGFR less than 25 mL/min/1.73m2: It’s not recommended to start, but patients can keep taking 10mg orally once a day to lower the chance of eGFR going down, ESKD, death from cardiovascular disease, and hHF.
  • Dialysis is not a good idea

How does dapagliflozin make you feel?

Dapagliflozin can have major side effects, such as:

  • See “Important information” above.
  • Ketoacidosis (more ketones in your blood or pee) in people with diabetes mellitus. During treatment with dapagliflozin, people with type 1 or type 2 diabetes have gotten ketoacidosis. People with diabetes who were sick or had surgery while taking dapagliflozin have also gotten ketoacidosis. Ketoacidosis is a serious disease that may need to be treated in a hospital. Ketoacidosis could kill you. With dapagliflozin, ketoacidosis can happen even if your blood sugar is less than 250 mg/dL. Stop taking dapagliflozin right away and call your doctor if you experience any of the following:
    • nausea
    • vomiting
    • stomach area (abdominal) pain
    • Getting tired
    • having trouble breathing

If you have any of these signs while taking dapagliflozin, check your urine for ketones, even if your blood sugar is less than 250 mg/dL.

  • Bad diseases in the urinary tract. People who take dapagliflozin have gotten serious urinary tract infections that could lead to a stay in the hospital. Tell your doctor if you have any signs or symptoms of a urinary tract infection, such as a burning feeling when you pee, the need to urinate often, the need to urinate right away, pain in the lower part of your stomach (pelvis), or blood in your urine. People may also get a fever, back pain, feel sick, or throw up.
  • Low blood sugar in people with diabetes, which is called hypoglycemia. If you take dapagliflozin with a drug that can cause low blood sugar, like a sulfonylurea or insulin, your chance of getting low blood sugar goes up. While you are taking dapagliflozin, you may need to take less of your sulfonylurea medicine or insulin. Low blood sugar can show up in a number of ways, such as:
    • headaches
    • shaking or feeling shaky, and being irritable.
    • quick heart rate
    • weakness
    • drowsiness
    • sweating
    • confusion
    • dizziness
    • hunger
  • A rare but dangerous bacterial infection called necrotizing fasciitis that affects the area between and around the anus and genitals (called the perineum). Women and men with diabetes who take dapagliflozin have had necrotizing fasciitis of the perineum. Necrotizing fasciitis of the perineum can cause a person to be hospitalized, need more than one surgery, or even die. See a doctor right away if you have a fever or are feeling very weak, tired, or uncomfortable (malaise) and you have any of the following symptoms between and around your anus and genitals:
    • pain or sensitivity
    • swelling
    • erythema, or redness of the skin.

Most people who take dapagliflozin will experience:

  • a stuffy or runny nose and a sore throat
  • changes in urination, such as the urgent need to pee more often, in larger amounts, or at night

These are not all of the things that could go wrong with dapagliflozin. Ask your health care provider or doctor for more information.

You should talk to your doctor about any side effects. You can call 1-800-FDA-1088 to tell the FDA about side affects.


Tell your doctor about all the medicines you take, including prescription and non-prescription drugs, vitamins, herbal products, and over-the-counter medicines.

Getting pregnant and nursing

If you are pregnant or want to get pregnant, you should tell your doctor. The drug dapagliflozin could hurt your developing child. If you take dapagliflozin and get pregnant, your doctor may switch you to a different blood sugar-controlling drug. If you want to get pregnant or are already pregnant, talk to your doctor about the best way to control your blood sugar.

Tell your doctor if you are breastfeeding or if you are planning to start. No one knows if dapagliflozin gets into your milk or not. If you take dapagliflozin, you shouldn’t breastfeed.


Keep dapagliflozin between 68°F and 77°F (20°C and 25°C) at room temperature.

What are the things that dapagliflozin is made of?

Active ingredient: dapagliflozin.

inactive ingredient: Microcrystalline cellulose, plain lactose, crospovidone, silicon dioxide, and magnesium stearate are some of the inactive ingredients. Polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and yellow iron oxide are all parts of the sheet coating.

Farxiga is the brand name for the drug dapaliglozin, which is sold by AstraZeneca Pharmaceuticals LP in Wilmington, DE 19850.

For more details,

Talk to your doctor or other healthcare source to make sure that the information on this page applies to your situation.

Medical Disclaimer

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