Cabozantinib is the generic name for the drug cabozantinib (KA boe ZAN ti nib) Cabometyx is a brand name.Multikinase inhibitors and VEGF/VEGFR inhibitors are two types of drugscaobometyx 

What exactly is Cabometyx?

Cabometyx (cabozantinib) is a kinase inhibitor, which is a type of enzyme inhibitor that inhibits the action of specific protein kinases. Cabometyx is used to treat advanced kidney cancer, and it is sometimes used with another drug called nivolumab.

Cabometyx is also used to treat liver cancer (hepatocellular carcinoma) in patients who have previously received sorafenib treatment.


Cabometyx has the potential to induce a perforation (a hole or tear) or a fistula (an irregular pathway) in your stomach or intestines.
This medication may potentially raise your chances of having major bleeding.

If you have severe stomach discomfort, choking or gagging when eating or drinking, unusual bleeding, bloody or tarry stools, heavy menstrual bleeding, or if you cough up blood, contact your doctor.  

Prior to using this medication,

Tell your doctor if you have any of the following conditions to ensure Cabometyx is safe for you:

  • an open skin wound (or a wound that is still healing);
  • Problems with bleeding (such as bloody or tarry stools, or spitting up blood or vomit that resembles coffee grounds);
  • elevated blood pressure;
  • liver illness or
  • a pre-existing dental issue

Before beginning this treatment, you may need to obtain a negative pregnancy test. Cabozantinib has the potential to damage an unborn child. To avoid pregnancy, use effective birth control while taking Cabometyx and for at least 4 months following your final dosage. Inform your doctor if you suspect you are pregnant. You should not breastfeed while using Cabometyx or for at least 4 months following the final dosage.  

Cabometyx should be taken as directed.

Cabometyx should be taken exactly as directed by your doctor.  Read all drug guides or instruction sheets and follow all guidelines on your prescription label.  Cabometyx tablets should not be used in place of Cometriq (cabozantinib) capsules.  Take just the pill type suggested by your doctor.  Always double-check the medicines you get from the pharmacist to avoid medication errors.

Cabometyx should be taken on an empty stomach, at least 1 hour before or 2 hours after eating anything.

Cabometyx should not be taken with food.

With a full glass of water, take this medication.  A pill should not be crushed, chewed, or broken, and a capsule should not be opened. Take the pill whole.  When taken in conjunction with Cabometyx, nivolumab is typically administered as an infusion into a vein once every 2 to 4 weeks.  Your blood pressure and liver function may need to be monitored on a regular basis.  


If you need surgery or dental work, you should stop taking Cabometyx at least three weeks in advance.  You may need to wait 2 weeks after a surgery or dental procedure before restarting Cabometyx.  Pay close attention to your doctor’s dosing instructions.  If you have stopped taking Cabometyx for whatever reason, consult your doctor before restarting it.  Keep away from moisture and heat by storing at room temperature.  

Dosing instructions

Adult Standard Dose for Renal Cell Carcinoma:

Tablets: -As a single agent: 60 mg orally once a day until clinical benefit is lost or unacceptable toxicity occurs.-When used in conjunction with nivolumab, 40 mg once daily until disease progression or intolerable toxicity.

When using this medication in conjunction with nivolumab, consult the nivolumab prescribing information.-In combination with nivolumab, authorised for the first-line treatment of patients with advanced renal cell carcinoma (RCC).

Adult Standard Dose for Hepatocellular Carcinoma:

Tablets: 60 mg orally once daily until clinical benefit is no longer obtained or unacceptable toxicity develops.

For patients with hepatocellular carcinoma (HCC) who have previously received sorafenib treatment.

What if I forget to take a dose?

Take the medication as soon as possible, but if your next dose is due in less than 12 hours, avoid the missed dose. Do not take two doses at the same time.  

What happens if I take too much?

Seek emergency medical treatment or dial 1-800-222-1222 for Poison Help.  

What should I stay away from while taking Cabometyx?

Grapefruit may interact with Cabometyx, resulting in undesirable side effects. While taking cabozantinib, avoid using grapefruit products.  

Cabometyx Adverse Effects

If you have any of the following symptoms of an allergic response to Cabometyx: hives; difficulty breathing; swelling of your face, lips, tongue, or throat, get emergency medical attention. Cabometyx has the potential to induce a perforation (a hole or tear) or a fistula (an irregular pathway) in your stomach or intestines. If you have significant stomach pain or feel like you’re choking or gagging when you eat or drink, contact your doctor.  

If you develop any of the following symptoms, contact your doctor right away:

  • severe headache, impaired vision, and pounding in the neck or ears;
  • Severe and continuous vomiting, diarrhoea, or constipation;
  • jaundice (skin or eye yellowing);
  • swollen hands, arms, legs, or feet;
  • easy bruising or bleeding (nosebleeds, bleeding gums, excessive monthly flow, or persistent bleeding);
  • If you experience specific side effects, your cabozantinib dosages may be delayed or withdrawn permanently.
  • crimson or tarry stools, coughing up bloody mucous, or vomiting that resembles coffee grounds;
  • pain, blisters, bleeding, or a severe rash in the palms of your hands or soles of your feet.
  • Confusion, difficulty thinking, weakness, alterations in vision, seizure;
  • a sense of dizziness, as if you’re about to pass out;
  • numbness or pain in the jaw, red or swollen gums, loose teeth, or poor healing following dental work
  • Fever, mouth sores, skin sores, sore throat, cough, and difficulty breathing due to low white blood cell numbers.
  • Adrenal gland issues include nausea, vomiting, excessive weariness, dizziness, weakness, and fainting.
  • Sudden numbness or weakness on one side of your body, problems with vision or balance, difficulty speaking or comprehending what is said to you, chest pain, difficulty breathing, swelling or pain in an arm or leg are all symptoms of a stroke or blood clot.
  • Cabometyx may cause the following adverse effects:
  • stomach cramps, nausea, vomiting, loss of appetite, diarrhoea, and constipation.
  • In your mouth or throat, you may have pain, redness, swelling, or sores.
  • Changes in taste, difficulty speaking;
  • Cold symptoms include a stuffy nose, sneezing, a sore throat, and a cough.
  • rash, aches and pains in your muscles, bones, and joints
  • abnormal liver function tests or other types of blood testing.
  • being fatigued;
  • loss of weight; or
  • The colour of my hair is lightening.

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